Some Causes Of Osteogenesis Imperfecta

Osteogenesis imperfecta. A group of genetic diseases of the bones. Divided into four types all result in brittle and frail bones. Multiple broken bones are common. Other features include deafness, white of the eyes appear bluish, kyphosis, kyphoscoliosis, tooth abnormalities, chest deformities and short stature. There is no specific treatment. Genetic counseling is important for families with the disease.

Brittle bone disease is caused by a mutation in the gene that controls the production of an important substance found in bone called collagen. This collagen material normally forms into a long rope that is composed of three tightly woven strands and is almost as strong as steel wire.

In osteogenesis imperfecta, however, the bone cells produce a defective form of collagen which is unable to form the triple-stranded rope. This results in a loose and very weak bone structure that does not contain enough calcium and that breaks easily.

Osteogenesis imperfecta is characterized by the following:

  • Frequent fractures
  • Progressive limb deformities
  • Loss of independent mobility
  • Chronic bone pain
  • Short stature

There is no cure for OI. Up until now, various treatments aimed at increasing bone mass and reducing the risk of fractures had been tried, but without significant success.

The following combinations are those recommended for people with brittle bone disease.

Vitamins : C
Minerals : Calcium, Magnesium, Zinc, Manganese, Silica
Food Supplements : Cod Liver Oil (for Vitamin D), Nutritional Yeast

The nutrients mentioned above reflect the major nutritional supplements that may help the condition. Please do remember however that nutritional supplementation is an adjunct to medical treatment and in no way replaces medical treatment.

Discuss It!